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Of even greater interest M-T7 treatment given alone, with no additional immunosuppressant treatment, also markedly improved survival of mouse renal allografts.
RV1 vaccine added to current diarrhoea treatment is highly cost effective compared to diarrhoea treatment given alone, with incremental cost effectiveness ratio of US$1122 per DALY averted, varying from US$80 2188 in sensitivity analysis.
It must be noted that the doses achieved here in this combination are approximately 50 60% of that achieved when each agent has been given alone with radical RT (Blackstock et al, 1999, 2003; Saif et al, 2005, 2007; Brade et al, 2007; Loehrer et al, 2008).
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33 To test the hypothesis that inhibition of hypoxia inducible factor-1 (HIF-1), when given with antiangiogenic agents, might be more efficacious, bevacizumab was given alone or with topotecan, a topoisomerase inhibitor, with HIF-1α inhibitor activity.
V-shoRT-R3 is a phase I/2 trial exploring the safety and the activity of capecitabine given alone or with VPA, during preoperative SCRT in patient with low-moderate risk rectal cancer.
To date, we do not know the true incidence of trastuzumab cardiac toxicity when it is given alone or with other antineoplastic drugs; the ongoing clinical trials, with careful cardiac monitoring, are likely to give us more accurate information Speyer, 2002.
Where 100 μg iv 14C-doses were given alone and with an oral non-labelled therapeutic dose, excellent accord between the PK parameters was observed indicating that the disposition kinetics of the drugs tested were unaffected by the presence of therapeutic concentrations.
Midazolam (0.01 to 0.025 mg/kg) was first given alone or with meperidine (0.17 to 0.25 mg/kg) either once or four times over two hours to whale #1102 by cantilevered pole syringe.
Moreover, adverse events were manageable and responsive to intervention regardless of whether ixabepilone was given alone or with capecitabine.
However, neutropenia was more severe following injection at 23 HALO as compared to 11 HALO, whether gemcitabine was given alone or with CDDP (P⩽0.001) (Table 1).
Gemcitabine dosing produced least body weight loss and least neutropenia after injection at 11 vs 23 HALO, whether the drug was given alone or with cisplatin (P=0.001).
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