Given a larger population and a higher incidence of diabetes, other parameters might have been included in the equations, but the discrimination and model fit may not be greatly improved.
Such results suggest that, given a larger population of highly exposed subjects, it is possible that statistically significant differences might have emerged between high and low exposure subgroups within the 2006 Kurttio et al. study.
More frequent cell division during development can result in enhanced fixation of mutations because of the reduced time available for repair of DNA lesions, and clonal expansion of mutant cells gives a larger population of mutants (Slikker et al. 2004).
But "all but impossible," given a large enough population, can become "rare but possible".
"Given such a large population base, there would be major fluctuations in population growth if we abandoned the one-child rule now," he said.
This potentially reflects a less motivated group of patients and/or less intensive monitoring during data collection given a larger study population as compared to the pilot cohort.
So Gemini gives Rosetta a large population to study, and Rosetta allows Gemini to study a large number of genes in that population.
Isaac Asimov's "Foundation," published in 1951, introduced the idea that, given a sufficiently large population, the broad movements of history like, say, the movements of a gas become statistically predictable.
Therefore, given a very large population of cells, such an error will be buried as noise.
As stated in the FDA's guidance on Drug-Induced Liver Injury, "…Finding one Hy's Law case in the clinical trial database is worrisome; finding two is considered highly predictive that the drug has the potential to cause severe DILI when given to a larger population".
