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While the positive predictive value was low (33.9%) given a fatality rate of 5.7%, the negative predictive value (NPV) was 99.7%, indicating that a child with a score ≤3 will likely respond well to standard treatment protocols.
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This gives a fatality rate of over 80% among known symptomatic disease cases.
There were no deaths giving a case fatality of 0% 955% CI: 0.0 5.2%).
There were 25 054 cases of P falciparum malaria, giving a case fatality of 0.73%.
There were 16 maternal mortalities due to peritonitis, giving a case fatality rate of 28%%.
Including only deaths from BC gave a case fatality rate ratio of 0.53 (95%CI 0.34 0.82).
Eight maternal deaths resulted from eclampsia and 1 from severe preeclampsia giving a case fatality rate of 16%%.
A trial of 38 patients in Jakarta examining dexamethasone 3 mg/kg followed by 1 mg/kg for a further 8 doses gave a case fatality of 2/20 for steroid treatment versus 10/18 for placebo (NNT of 3) [ 62].
Seven deaths were associated with non-falciparum malaria, (four from P vivax, and one each from P ovale and P malariae) among 13 804 cases, giving a case fatality for non-falciparum malaria of 0.05%.
Four patients died as a result of complications from IPD giving a case-fatality rate of 8.0%95%5% CI: 2.4%-22%).
Thirty-three hospatientsd patients with a diagnosis of VE died, giving a case-fatality ratio (CFR) of 7.9% (Table 1; Figure 3, panel A); CFR was highest among those80 84 years of age.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com