Patients had been given a marker chemical called bromodeoxyuridine (BrdU), which is incorporated into the DNA of dividing cells, to follow the growth of their tumors.
Therefore, given a marker position in the 50K Affymatrix genotype data, all lower and upper 2.5K SNPs around each of the 50K SNP markers were extracted from HapMap and named the 5K_HapMap dataset.
Our methodology is entirely based on estimated response rates given a marker.
Using this information we can estimate the overall response rate given a marker, for each of the markers considered.
Using the mutation status of each gene and the estimated response rates given a marker we can estimate the response rate of each patient in an approximate manner.
The rationale behind genomic selection in livestock is that, given a marker density high enough to cover the entire genome, most of the quantitative trait loci (QTL) will be in high linkage disequilibrium (LD) with some of the markers.
Monitoring the response will give a surrogate marker of endothelial performance post-fistula formation and therefore guide vascular surgeons regarding patient suitability and vascular access site placement.
