Sentence examples for giant larva from inspiring English sources

He produced a giant larva by fusing two embryos.

We have included the gene name (Lethal giant larva (l(2 gl)) in text.

In both cases a deletion affecting the same genes: the human homologue of the Drosophila flightless-I gene (FLII); cytosolic serine hydroxymethyltransferase (SHMT1); 21,23 the human homologue of Drosophila lethal 2 giant larva (LLGL1); and 18 topoisomerase IIIa (TOP3A), was found confirming the clinical diagnosis of SMS.

The polyps in patients hemizygous for a defective APC (disrupting the wnt/wingless pathway) and the dysplasias preceding neoplasia both in retinoblastoma and in the lethal giant larva mutant in Drosophila that eventually result in neuroblastomas are tissue organization alterations in which the underlying cause may be altered morphogen/morphostat gradients [ 1].

The Lethal giant larvae (Lgl) tumor suppressor family is conserved from yeast to mammals and plays a critical yet controversial role in cell polarity.

In brief, aPKC phosphorylates and inhibits Lethal (2) giant larvae (Lgl) at the posterior cortex, such that active nonphosphorylated Lgl protein is restricted to the anterior cortex where it promotes the cortical localization of Numb and Neur [7], [8].

The Baz (fly PAR-3) complex (cytoplasmic Baz, PAR-6, aPKC and Cdc42) and the Crumbs (Crb) complex (transmembrane Crb, and cytoplasmic Stardust and Patj) are apical cues, whereas the Discs large (Dlg) complex (cytoplasmic Dlg, Lethal giant larvae and Scribble) is a basolateral cue.

The line E00321 is homozygous lethal and carries an insertion in lethal (2) giant larvae.

In contrast, global Wnt signalling will deplete Lethal giant larvae within the whole cell, preventing polarization.

Here, we have dissected the role of the three aPKC phosphorylation sites within the tumor suppressor Lethal giant larvae.

Lethal (2) giant larvae (abbreviated Lgl) was identified by several groups as the key substrate for aPKC [ 49- 51].