Sentence examples for giant cell death from inspiring English sources

We next investigated the mechanism and the timing of giant cell death.

To investigate whether ICL induces giant cell death in a human cancer cell, we analysed HN1- and HN2-treated HeLa cells.

In the current study, ICL-damaged cells showed transient mitosis and a novel giant cell death in the tetraploid G1 phase following the prolonged G2 arrest.

Lower concentrations (GI50) of HN2-treated, H2B-GFP-expressing HeLa cells showed the formation of giant cells with enlarged nuclei and, consequently, giant cell death.

XRCC3-deficient cells did not show giant cell death, but cell death after cell division, followed by relatively normal chromosomal segregation compared with AA8 cells in response to equitoxic HN2 treatment.

Interestingly, this 'giant' cell death was not observed in XRCC3-defective cells, suggesting that ICL repair, especially by HR, participates not only in the maintenance of G2 arrest, but also in ICL-induced 'giant' cell death.

This characteristic 'giant' cell death, observed by using time-lapse video microscopy, was reduced in ICL repair ERCC1- and XRCC3-deficient cells.

It is therefore likely that the abnormal chromosomes that triggered 'giant' cell death resulted from aberrant repair of ICL damage (e.g. over-processing of ICL damage repair and/or an excess of recombination events).

Detection of early changes in membrane permeability of living neuronal cells identified giant membrane depolarization and subsequent cell death evoked by the protein-like PAMAM G5-NH2 dendrimer.

In contrast, p53-deficient cells exposed to SP600125 undertook a series of abortive mitoses (featuring karyokinesis but no cytokinesis), eventually generating giant cells that finally underwent apoptotic cell death.

Loss of cell polarity genes, including s cribble (scrib), lethal giant larvae (lgl) and disc large (dlg), results in Bsk-mediated cell death and elimination from the tissue.