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These findings are of particular relevance for patients requiring long-term, continuous anti-inflammatory therapy, who may otherwise need to discontinue treatment because of upper GI side effects.
Some GI patients medicate with OTC NSAIDs for pain, and take additional OTC GI medications for GI side effects [16] which may increase their risk of drug-related interactions, unknown to the clinician.
There were also significantly fewer GI side effects in this group.
Conclusions: Sodium phosphate tablets, compared with PEG solution, produce equivalent colon cleansing, are associated with fewer GI side effects, and are better tolerated by patients.
Clinical use of NSAIDs is limited due to adverse reactions such as GI side effects and renal side effects when given orally.
Celecoxib was introduced as a COX2 selective inhibitor that avoided the adverse GI side effects of oral non-selective NSAIDs [29].
A study estimated that one third of the total cost of treating patients with OA is dedicated to treating the NSAID-induced adverse GI side effects that occur in up to 25% of the patients [101].
Neutropenic enterocolitis and typhlitis (neutropenic enterocolitis of the cecum) are the most common GI side effects of chemotherapy, and are associated with several cytotoxic breast cancer drugs including doxorubicin, docetaxel, paclitaxel and platinum agents.
Gradual dose increments prevent GI side effects.
Some small studies suggest that GI side effects may be fewer with risedronate than alendronate [ 110].
Dose reduction can also be used to reduce GI side effects.
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