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GABA-mediated neurotransmission is known to play important roles in gestational brain development, and the theory that altered GABA metabolism could play a role in ASD has been advanced (Cohen 2001).
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The support for an association between gestational nutrition and brain development has been particularly strong for iron, n-3 fatty acids, and folate [ 6- 8].
Because heterogeneity of the autism phenotype and its severity may be attributable to influences on different critical gestational windows of brain development (Geschwind and Levitt 2007), we also seasonalized these traffic measures to investigate vulnerable trimesters of development.
The deleterious effect of gestational hypothyroidism on fetal brain development is well documented (de Escobar et al. 2004).
Hence, it is important to determine whether a gestational KD indeed alters early brain development.
Globus pallidus MRI relaxometry measures the impact of gestational age at birth on brain development independent of postnatal age in preterm infants and should prove useful for predictive modeling in a flexible time-window around postmenstrual term age.
The ovine fetus is an excellent model to study brain development since the entire gestational equivalent of human brain development occurs in utero [ 7].
On postnatal day 10 of pups, corresponding to the brain development of 40-week gestational age in human fetus [ 11], pups were anesthetized with isoflurane (3%) inhalation.
Given that term in mice corresponds to gestational day ~120 in humans with respect to brain development, the finding of El-Khoury et al. (2006) is in good agreement with the situation in mice in which AQP4 positive endfeet emerge during the first postnatal days.
Support vector regression enabled quantitative estimation of birth gestational age in single subjects using only term equivalent resting state-functional MRI data, indicating that the present approach is sensitive to the degree of disruption of brain development associated with preterm birth (using gestational age as a surrogate for the extent of disruption).
In addition, gestational 25(OH D concentrations are associated with normal fetal brain development, and levels above 30 ng/ml are associated with reduced risk of childhood neuropsychological impairments, and development language difficulties.
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