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Stem Cell-Niche Interactions We are examining the cell biological aspects of cell-cell and cell-basement membrane establishment of the germ stem cell niche.
It has a completely sequenced genome facilitating gene identification and reverse genetics, male germ stem cell line capable of sperm production in vitro [24], the ease of observation of germline development and robust genetic manipulations in embryos [25] and stem cell cultures [26].
Further understanding and potential manipulation of the adult female germ stem cell niche may provide answers.
A further understanding and potential manipulation of the adult female germ stem cell niche may provide the answer.
This phenomenon might result from a paternal age-dependent germ stem cell selection process, whereby the selected stem cells have longer telomeres, are more homogenous with respect to telomere length, and share resistance to aging.
When wild type ovaries are radiation challenged, functional p53 activation is seen only in the stem cell and their immediate progeny – under these conditions, the p53 biosensor is never observed outside of the germ stem cell compartment.
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Komai Y, Tanaka T, Tokuyama Y, Yanai H, Ohe S, Omachi T, et al Bmi1 expression in long-term germ stem cells.
In the current study, effects of boron on the cryopreservation of human tooth germ stem cells (hTGSCs) were evaluated for the first time.
The seeding cells, however, for tooth regeneration such as odontoblasts from dental germ, stem cells from dental pulp and deciduous teeth, and ectomesenchymal cells from the first branchial arch are difficult, even impossible to harvest in clinic.
We are particularly interested in how somatic and germ cells interact to maintain the germ stem cells.
And if researchers can find ways to preserve some germ stem cells, or identify drugs that don't target them, Tilly suggests, fertility could be protected--even if existing oocytes are killed by treatment.
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