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As a result of smoothing, a different geographical pattern for SMR in both genders was observed.
Although differences in reproductive factors among populations are important, a similar geographical pattern for breast cancer in men has been found (Thomas, 1993).
These previous studies are different from our results, suggesting that there may be a geographical pattern for urease production, an observation further confirmed by the fact that urease activity was observed in 151 Brazilian Sporothrix spp. strains [ 34].
We observed a statistically significant geographical pattern for community-acquired infections with higher incidence in the city of Rome (standardised incidence rate 114, 95%CI 104 125) and in the suburbs (standardised incidence rate 108, 95%CI 94 124) a lower incidence in rural areas (standardised incidence rate 65, 95%CI 56 76).
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We found different geographical patterns for infant and child mortality.
When compared to other European and Middle East populations, we observed geographical patterns for H1, H3 and H5a that are statistically clinal, with frequency peaks in the Franco-Cantabrian region decreasing towards East Europe.
If such geographical patterns for chronic diseases such as diabetes are confirmed in other places, the data offer the prospect of more geographically targeted interventions to reduce health risks related to diabetes.
geographical pattern of vegetation [6].
However, each disease has a distinct geographical pattern of variation.
Geographical pattern of cause-specific mortality risk was not done in the present study, but it is a potential subject for future research.
For men, the inequalities are in general smaller and no clear geographical pattern emerge for Southern, Central, and Northern Europe [ 5, 27].
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