A phylogenetic analysis of the complete Rep protein of DogCV strains and all known circoviruses was performed, with chicken anemia virus (genus Gyrovirus) as the outgroup.
Chicken anemia virus (CAV) is the member of the genus Gyrovirus of the family Circoviridae, and the genome consists of a circular single-stranded 2.3 kb DNA molecule [ 1].
The chicken anemia virus (CAV), is a known member of the genus Gyrovirus and was first isolated from chickens in Japan in 1979.
Chicken anemia virus (CAV), initially the sole member of the genus Gyrovirus (family Circoviridae), possesses a genome of ≈2.3 kb, containing 3 major partially overlapping open reading frames, viral proteins [VP] 1 3, and a short untranslated region (1 ).
For phylogenetic studies, the sequence of Chicken anemia virus (CAV; accession number M55918), a member of the genus Circovirus in the family Circoviridae, was used as an out-group.
This virus belongs to the genus Gyrovirus of the Circoviridae family and causes a severe immunosuppressive syndrome and anemia in chickens [ 2].
The new isolates had the same genome segment order and the closest pairwise amino acid sequence identities of 16 42% with Infectious salmon anemia virus (ISAV), the type species and currently only member of the genus Isavirus in the family Orthomyxoviridae.
The infectious salmon anemia virus (ISAV) is a negative single-stranded RNA virus assigned to the genus Isavirus within the family Orthomyxoviridae.
The characteristics of its genome a single, closed molecule of circular, negative-sense DNA ≈2,300 nt long and sequence homology with the chicken anemia virus (CAV) have suggested that HGyV might be the first human-infecting member of the genus Gyrovirus, which is part of the family Circoviridae and encompasses only 1 previously known species, CAV (2 ).
Various species of the genus Flueggea are used to treat many diseases including epilepsy, malaria, jaundice, intestinal worms, edema, heavy menstruation, sterility, poliomyelitis and aplastic anemia in many African and Asian countries [ 6].
