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This means that the standard deviations over orientations, see Fig. 5, are not due to inadequate validation of the classifier but a genuine variation in descriptor performance.
Studies that rule out differences in estimation methods and data years show that little of this is due to genuine variation in preferences across countries (Bargain et al. 2014).
The changes we identified were expected to include both genuine variation between the N2 and LSJ1 genomes and sequencing errors in the N2 reference sequence or in our Illumina data.
This represents a moderate level of inconsistency attributable to genuine variation in gene effect size.
The analysis indicated a moderate level of heterogeneity attributable to genuine variation in gene effect size (I = 37%).
The difference, however, is not simply an artefact of mis-measurement; it is also an artefact of genuine variation in individual blood pressure across settings.
Similar(48)
Thus, these SNPs are genuine variations from the reference sequence, but are not pathological.
This selection was chosen for simplicity and could certainly be improved, as it is well-known (Campbell, 1979; Torta et al., 1997; Janzhura and Troshichev, 2008) that special attention has to be paid to the selection of the representative quiet days for the definition of the genuine Sq variation.
If cases and controls are run in separate batches, genuine biological variation can be entirely confounded by batch effects.
However, even when all reasonable safeguards are taken, the issue of how to discern genuine novel variation from sequence or human errors remains, especially when working with the degraded templates typical of ancient DNA (aDNA)[30] [32].
These differences may reflect genuine geographical variation but are likely to be due to methodological inconsistencies.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com