Sentence examples for genuine domain from inspiring English sources

Some sequence divergence or even a small mis-annotated region may be sufficient to disrupt alignment between a domain PSSM and the sequence, but the presence of an extra domain may point to genuine domain shuffling or long mis-annotated regions.

Although the genuine domain content of a real microbial metatranscriptome is unknown, the results obtained from the Gilbert and Stewart metatranscriptomes were, in terms of data reduction and annotation rates, consistent with the medium and high diversity 454 simulations (see Additional file 1: Figure S4).

Here, we show that the minor spliceosomal protein U11-48K contains a genuine CHHC Zn-finger domain.

If the −41 bp variant does highlight a genuine regulatory domain of GDF5, then this may offer us with a DNA site that could be exploited to manipulate the expression of the gene and therefore potentially alleviate the detrimental effect that the T-allele of rs143383 has on GDF5 expression and therefore on OA risk.

It is therefore unclear whether these sequence segments are genuine POTRA domains, or might instead represent novel, long intervening regions rendering more flexibility to the respective POTRA arms.

All the retrieved sequences were used as queries to undertake similarity searches using BLAST algorithm against the NCBI protein database to ascertain that they corresponded to genuine bHLH domains.

As a result, imposter feature components might be misclassified as genuine in the Hamming domain and eventually, the discretization performance would be greatly impeded by such an imprecise discrete-to-binary map.

In such cases, additional knowledge, or further classification of the domains into sub-families [28], is required to differentiate between CM proteins containing 'Actin' domains, and genuine false positives due to "contaminations" coming from the negative training sets.

Certainly it would have been better if all three parties had looked for genuine achievements in recognized domains -- like mathematical precociousness, success in chess, excellence at golf -- rather than for high test scores.

The latter model of membrane associated NS3 expression system was particularly important since it should more precisely mimic the intracellular localization of the genuine viral-encoded NS3 protease domain.

Our experimental analysis confirms that this domain is a genuine Zn-binding module that in isolation behaves as an independent folding unit.