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Yet the clinical use of genotyping prior to drug prescribing and dispensing is not widely practiced.
In addition, the application of genotyping prior to acenocoumarol and phenprocoumon prescription needs to be assessed, although suitable dosing algorithms will need to be formulated.
Based on clinical presentation, epidemiologic characteristics, geographic location, and genotyping, prior studies have identified 2 distinct MPXV clades, WA and CB [ 4, 5].
To avoid adverse effects, it is recommended to perform accurate genotyping prior to treatment decisions that include drugs sensitive to the allelic composition of genes involved in their metabolism (Cavallari, 2012).
We have recently undertaken a randomised controlled trial of genotype-guided dosing versus standard clinical practice [ 11] - this showed that genotyping prior to warfarin prescription increased the time within therapeutic range of international normalised ratio (INR) between 2.0-3.0 by a mean of 7.0%%.
American Association for the Study of Liver Disease AASLDD) practice guidelines recommend quantitative PCR for HCV RNA for quantification of viral load and HCV genotyping prior to antiviral therapy in CHC patients [ 10]; same has been proposed by the European Association for the Study of the Liver (EASL) [ 11].
Similar(54)
(2) Phenotypic variation of ion contents in segregating populations can be increased by selecting parental genotypes prior to intercrossing based on microsatellite markers.
Implications for engineering salt tolerance are: (1) Improving salt tolerance can be achieved by selecting parental genotypes prior to intercrossing based on microsatellite markers.
Tail biopsies were clipped during dissection and genotyped prior to sample harvesting to identify WT and KO pups.
Mice were genotyped prior to the behavioral experiments, but the identities of the mice were not exposed to the experimenter during the behavioral experiments.
Treatment of hearts with MSC of either genotype prior to ischemia resulted in significantly improved post-ischemic functional recovery as compared to vehicle controls.
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