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A genotyping-oriented strategy, solely based upon the realization of genotyping exams on all the flock animals, becomes a valuable alternative to the preceding pedigree-oriented strategy.
Strategies defined above use preferentially either diagnostic tests, or genotyping exams, or both.
The corresponding durations were evaluated, as well as the associated costs: numbers of diagnostic tests and genotyping exams performed.
Global cost for substantiating freedom from scrapie depends upon the unitary costs of genotyping exams and of diagnostic tests.
In particular, if the unitary cost of genotyping exams was very low (ratio of 0.1), strategy A2 was the less costly strategy for 60% of simulated flocks.
Thus performing diagnostic tests and genotyping exams on all culled animals does not allow demonstrating scrapie absence within a reasonable time horizon (10 years).
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The less costly strategy varied according to the genetic context (resistant or susceptible) and to the relative costs of a genotyping exam and of a diagnostic test.
Conversely, if the cost of a genotyping exam was more than half that of a diagnostic test, the strategy with the lowest associated cost was C1.
If the cost of a genotyping exam was less than half that of a diagnostic test, the strategy with the lowest associated cost was A2.
In particular, even if the cost of a genotyping exam is very low (ratio of 0.1), strategy C1 remained the strategy with the lowest cost in approximately 3/4 of simulated flocks.
In particular, when the cost of a genotyping exam is less than half the cost of a diagnostic test (which corresponds to the present situation in France), this genotyping-oriented strategy becomes the lowest-cost strategy.
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