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The questions raised by Rodriguez-Lopez and colleagues [ 1] provide further incentive to build common platforms for phenotype definition, inclusion criteria, genotyping and analytical methods, and to unite the ethnically diverse resources available for study.
To benefit fully from the contribution of genetics, large prospective studies need to be designed, fully supported by extensive genotyping and analytical capacities.
Investigations using larger samples and advances in both genotyping and analytical methodologies will be crucial to success in unraveling the causal pathway for this common and serious cause of healthcare-associated infection.
Future investigations using larger samples, narrowed phenotypes, and advances in both genotyping and analytical methodologies will be important tools for identifying causative variants for this common and serious cause of healthcare-associated infection.
There are important variations in study populations (e.g., race/ethnicity, smoking history, exclusion of subjects with other illnesses, other criteria used for selection, study design, and informed consent restrictions) and genetic analysis approaches (e.g., variation in genotyping platform, data cleaning, analytical approaches, and data sharing).
Analytical specificity of genotyping assay is as or more important than analytical sensitivity and should be considered in selecting assay to monitor HPV.
Analytical specificity of genotyping assay is as or more important than sensitivity and should be considered in selecting assay to monitor HPV.
Some limitations were common to all the methods tested in relation to typing oocysts recovered from water samples and are not identified in Table 2. Watershed managers can send Cryptosporidium-positive water samples to analytical laboratories for genotyping and subtyping (Jiang et al. 2005; Ryan et al. 2005; Xiao et al. 2000, 2001; Zhou et al. 2003).
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