Sentence examples for genotypic modification from inspiring English sources
Such vectors require modification at the genomic level in the form of rearrangements to allow introduction of desired genes and regulatory elements (genotypic modification) as well as engineering of the physical virus particle (phenotypic modification) in order to mediate efficient and safe delivery of the genetic information to the target cell nucleus.
Interestingly, the only somaclone showing an atypical phenotype (asymmetric leave) shows a genotypic modification.
To confirm that these genotypic modifications were consistent with the phenotype expressed by these variants, insertion mutants were engineered by introducing the cat gene, conferring resistance to chloramphenicol, in hpuA and the spectinomycin resistance cassette in hmbR.
Accordingly, the pathology and clinical manifestations of the disease could be correlated to the genotypic modifications.
Accumulation of kDNA mutations, recombination, and hitchhiking, with the associated genotypic and phenotypic modifications, likely will drive pathology.
19– 22 Different strategies to improve the sensitivity of genotypic methods to detect X4 variants have been examined, including simple modifications in the interpretation algorithms, 23 or adding structural/biochemical properties of the V3 loop and clinical parameters such as CD4 and CD8 counts, and plasma viremia in the final report interpretation.
Albino tadpoles comprised 26%and16%6% of the offspring derived from crosses between albino females and 1.6-pg-mRNA-injected m4 and m5 males, respectively, and the gene modification rate in the m5 spermatozoa was estimated to be 28% using genotypic analysis (Table 1).
Furthermore, aberrations mediated through post-translational and epigenetic modifications as well as stochastic and unpredictable behavioural diversity of subclones with similar genotypic identities (Kreso et al, 2012) are likely to complicate the picture of intratumour heterogeneity further.
Therefore, this study, which aims to investigate the prevalence and patterns of HIV-1 genotypic resistance among antiretroviral-treated Thai patients in 2002, may provide valuable information that could guide the modification of regimen and treatment strategies.
Genotypic frequencies were calculated.
