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Collectively, these results highlight that the SNPs identified among ptxP3 strains will serve as potential genotypic markers in phylogenetic genotyping studies, particularly in the monitoring of ptxP3 strains worldwide.
Calling of the results: For each isolate analyzed the genotype was called if no intermediate genotypic markers were present or flagged for final interpretation by an expert if the MFICORR of one or more genotypic markers was in the grey area (intermediate).
Hence, we aimed at detecting genotypic markers of the metastatic sub-clones within the heterogeneous primary tumour population.
The experimental approach included a conditional knockout strategy with three genotypic markers, which greatly facilitated the generation and phenotypic identification of targeted recombinant cells.
In this review, we described phenotypic and genotypic markers of nucleotide excision repair (NER) that have been used in molecular epidemiology studies.
This was done by serial passage experiments in glioma xenografts in vivo and investigation of phenotypic and genotypic markers of attenuation.
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Thus, expression microarrays hybridized with RNA are able to provide us not only with phenotypic (variation in gene expression) but also with genotypic (marker) data (Zhu and Salmeron 2007).
The rs4586 SNP may be useful as a simple, non-invasive, genotypic marker able to predict low counts of MLs in CSF and aid in appropriate clinical assessment of suspected TBM.
This experiment was carried out before the genotypic marker (see below) was available.
Previously we called the presence or absence of a genotypic marker based on a threshold signal level.
Genotypic marker data from previous mapping studies and the present study in each population were combined for linkage analysis.
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