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We compared phenotypic and genotypic features of adults patients whose disease started during childhood (Group 1, n = 28) with those of patients whose disease started at adult's age (Group 2, n = 114).
Adult patients (>18 years old) with mastocytosis were recruited prospectively through the French mastocytosis network (AFIRM M« French Association for the Initiatives of Research on Mastocyte and Mastocytosis», protocol "Physiopathological and clinical study of mastocytosis in adult patients") to compare phenotypic and genotypic features of patients according to their age of onset.
Phenotypic and genotypic features of these 2 strains are described.
Table 1 summarizes the demographic, clinical and genotypic features of the seven patients.
In the study described herein, the phenotypic and genotypic features of carbapenem-resistant Enterobacteriaceae strains isolated in our hospital were evaluated.
Primary leukaemia cells engrafted into NOD/SCID mice appear to retain many of the phenotypic and genotypic features of the original specimen [ 2, 7- 10].
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The frequencies of these two genotypic features at the end of the experiment are 23% and 51%, respectively.
Such small mutations can also be included into the list of genotypic features, and associated to phenotypes in the same way as presence/absence patterns of OGs or phages (above).
What genotypic features explain the evolvability of organisms that have to accomplish many different tasks?
Machine learning (ML) algorithms could eventually integrate a wider array of genotypic features extractable from pathogen genomes variant calls, putative gene and motif annotations, and more and train holistic models that predict phenotypes.
Our study shows how the phenotypic variability in multiple myeloma bone disease can be understood through the theoretical approach of a game that allows the identification of key genotypic features in a tumour and provides a natural explanation for phenotypic variability.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com