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The cytokine-cytokine receptor pathway was significant for both allele and genotype tests for fetal data.
The complement and coagulation pathway had a significant excess of associations for both the allele and genotype tests in maternal data.
In the maternal data the genes in complement and coagulation pathway had a significant excess of associating SNPs in both the allele and genotype tests compared to expected results (Table 8).
Relying on a significant genotype tests using a log-additive model would have excluded 57% of the non-replicated and none of the replicated loci, while use of other SNP features and clustering might have missed true associations.
Multilocus analyses on pathways with an excess of significant associations for either allele or genotype tests (identified by Z tests analyses) revealed a statistically significant two locus model in the complement and coagulation pathway in maternal data after excluding the single most significant tPA marker (rs879293) (Figure 1).
For diplotype data, haplotype and composite genotype tests are performed.
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P values for genotypic distributions were calculated with the global genotype test.
But I had in my hands the results of a genotype test in which her particular viral strain had been probed for the gene patterns that predict resistance to new drugs I plan to use.
Two authors of the study own shares in Interleukin Genetics, the company that makes the genotype test for interleukin-1.
Second, the sensitivity of ligand binding to genotype requires genotype testing for each study participant.
Patient CYP450 genotype testing can predict altered pharmacokinetics, and is currently available and relatively inexpensive.
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