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For analysis of genotypic association of these seven SNPs under certain genotype models (Table 4), rs2353397 TT protected subjects from the disease; CC, CT carriers were more susceptible to COPD (OR=1.01, 95% CI 0.79 1.32, p<0.0001).
The most significant allelic and/or genotypic associations were followed up with additive, dominant and recessive genotype models, using the minor allele as the risk allele, using logistic regression.
OR are derived from genotype models (2df).
We used an approach free of assumptions and built genotype models (2df).
We then calculated study-specific and pooled odds ratios (OR) and 95% confidence intervals (CI) assuming allele and genotype models.
We used logistic regression analysis to investigate the association between bi-allelic and tri-allelic genotypes and triptan non-response with genotype models.
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The results from the genotype model remained very similar.
Employing a genotype model in addition to an allele model yields further valuable information.
Another study [13] did not show an association of any of the genotypes with any of the migraine categories in either the allele or the genotype model.
Table 4 summarizes results from the pooled and meta-analyses based on an allele model and Table 5 a pooled analysis based on a genotype model.
Results from the genotype model suggested a reduced risk of the 10/12 and 10/10 genotypes for any migraine [10, 12], MA [10, 12] or MO [10] compared with the 12/12 genotype.
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