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For future work, however, comparative genomics with multiple human genome sequences offers a relatively bias-free approach for the random or comprehensive sampling of microsatellite loci when applied to the genome sequences of many individuals of the same species.
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The comparative genomics analysis conducted here is thus the first systematic study of the distribution of a regulatory network in genomes with multiple chromosomes.
DS has been investigated with multiple functional genomics studies aiming to understand the molecular basis underlying the various aspects of the disease [ 4- 7].
A main result of the comparative genomics analysis over several phylogenetic groups containing species with multiple chromosome genomes is the observation that the core genes of the SOS response are found predominantly in the large chromosome.
The pathogenesis and psychopathophysiology of AN can be better elucidated by combining longitudinal phenotyping with multiple "omics" techniques, including genomics, proteomics, lipidomics, and metabolomics.
Few comparative genomics studies have analyzed regulatory networks in species with multiple chromosomes and none of them has done so in a systematic way.
In conclusion our results show that random anchor based approach with multiple distance measures can be very useful in comparative genomics, particularly in deciphering evolutionary relationships among organisms and identifying diverse regions in different genomes.
As systems biology begins to take hold and bear fruit, there will be an increasing opportunity for scientists with multiple degrees: information technology with biology, statistics or mathematics with bioinformatics, pharmacology with genomics, and so forth.
Employing genetical genomics, we showed that this approach is valuable for elucidating interactions between genes that originate from complex families with multiple related sequences.
The data were quantile-normalized and a 3-way ANOVA with multiple test correction using the false discovery rate (FDR, significance at 0.05) [43] was performed using Partek Genomics Suite software (Partek, inc. St . Louis Mo., v6.5 6091110).
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