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In this commentary paper, we discuss recent studies on the genomic taxonomy of diverse microbial groups and a unified species definition based on genomics.
Defining the tissues where the kinase genes were transcriptionally active led to a functional genomic taxonomy of the kinome and a classification of human tissues and disease types based on the similarity of their kinome gene expression.
To validate our genomic taxonomy of NSCLC, we correlated the genomic classification with disease outcomes.
This study aimed at providing the underpins for the establishment of an online genomic taxonomy of vibrios.
We believe that copy number profiles are best suited for developing a genomic taxonomy of cancer due to their temporal stability and easier detection in various samples.
Similar to our observations in the study of the genomic taxonomy of vibrios, Mycoplasma species may be defined based on genomic features, such as DNA identity in MLSA, AAI and Karlin genomic signature.
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In support of our view, several studies have advanced the utility of a genomic taxonomy for prokaryotic species delineation [ 54, 70, 71].
In Vibrios, the birth of the genomic taxonomy occurred with a series of papers that attempted to use multilocus sequence analysis (MLSA) [ 21- 26].
In order to test the feasibility of the genomic taxonomy in vibrios, several markers were analysed in a collection of 32 genomes, including four newly pyrosequenced genomes.
This endeavour will culminate in the birth of the online genomic taxonomy whereby researchers and end-users of taxonomy will be able to identify their isolates through a web-based server.
The growing evidence obtained by various studies demonstrates the usefulness of genomic taxonomy.
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