Sentence examples for genomic subtypes we from inspiring English sources
To further characterize the identified genomic subtypes, we used available classification according to the intrinsic gene-expression subtypes, as well as other signatures derived from gene-expression analysis of all tumors.
Thus, to identify breast cancer genomic subtypes that are more relevant, we envisage that it will be necessary to derive and analyse multi-dimensional mutational profiles.
To investigate whether the identified genomic subtypes showed an association with the outcome, we performed Kaplan-Meier analyses by using OS as end point.
To confirm the observation that luminal A cases in the luminal-simple subtype show a trend toward better clinical outcome than other luminal A cases, we created gene-expression centroids for the genomic subtypes based on genes from the Hu et al. [ 4] gene list (Additional File 1).
To test this hypothesis, we constructed gene-expression centroids for the different genomic subtypes and applied them to two independent breast cancer gene-expression data sets.
Two genomic subtypes are distinguished by chromosome 9q loss, resulting in increased AKT/PI3K/mTOR signaling.
Attesting to the molecular heterogeneity of MM, unsupervised classification using nonnegative matrix factorization (NMF) designed for array comparative genomic hybridization (aCGH) analysis uncovered distinct genomic subtypes.
With the high correlation of TP53 mutation and genomic instability in ESCC, the amplification of CCND1, the deletion of CDKN2A/2B, and the somatic mutation of TP53 appear to play pivotal roles via G1 deregulation and therefore helps to classify this cancer into different genomic subtypes.
Thus we show that disruption of activin signaling occurs in MSI and MSS colon cancers by distinct mechanisms, revealing activin signaling as an important target in the two most common genomic subtypes of colon cancer.
Four unique genomic subtypes were identified using unsupervised hierarchical clustering.
Additionally, tumors from BRCA1 and BRCA2 mutation carriers were found in distinct genomic subtypes.
