Sentence examples for genomic subtypes defined from inspiring English sources

Clinicians should be highly encouraged by the four major genomic subtypes defined by TCGA that show distinct salient genomic features, providing a guide to targeted agents that should be evaluated in clinical trials for distinct populations of gastric cancer patients.

If we identify higly heritable components of a complex disease, it could also improve the utility of genomic prediction methods to predict subtypes (defined by the components) of the disease.

So far, four main genomic subtypes that roughly correlate with the well-known intrinsic subtypes defined from gene expression studies have been identified [ 1, 2].

Extensive genomic analysis of breast cancers discloses four coherent groups [ 13], similar to the intrinsic subtypes defined by gene expression profiling [ 14].

Each class comprises different subtypes defined by the expression of multiple specific markers.

Tumor subtypes defined by these receptors present biologically different features.

Subtypes defined by clinicopathological criteria are similar to but not identical to intrinsic subtypes and represent a convenient approximation.

Molecular subtype defined by IHC was an independent prognostic factor.

Two genomic subtypes are distinguished by chromosome 9q loss, resulting in increased AKT/PI3K/mTOR signaling.

Attesting to the molecular heterogeneity of MM, unsupervised classification using nonnegative matrix factorization (NMF) designed for array comparative genomic hybridization (aCGH) analysis uncovered distinct genomic subtypes.

Four unique genomic subtypes were identified using unsupervised hierarchical clustering.