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The genomic subtype classification has shown clinical application for prognosis in patients receiving only surgical treatment without adjuvant therapy [ 11], and adjuvant endocrine blockade without chemotherapy [ 14].
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To investigate whether luminal-simple-classified luminal A tumors also showed lower FGA in independent data sets, we analyzed the Chin et al. [ 3] aCGH data set by using the genomic-subtype classification from corresponding gene-expression data in the combined Affymetrix data set.
Even in multivariate analysis, the genomic profile (the classification into genomic subtype) is still statistically significant and therefore provides useful additional prognostic information [ 40, 69].
Subtype classification based on one genomic region however, may miss intersubtype recombination [ 9].
Heterogeneity, particularly intratumoral heterogeneity, increases the challenges of cancer subtype classification.
In subtype classification model, the two classes were activated B-cell-like subtype and germinal center B-cell-like subtype.
Figure 1 shows the IFS curve for (A) subtype classification model and (B) survival prediction model.
The mRNA expression derived subtype classification has previously been performed and presented [8].
Our methodology provides a way to study subtype classification and survival prediction simultaneously.
Knowledge about subtype classification can improve performance on survival prediction, and vice versa.
was consulted when the subtype classification could not be decided on by the initial 3 reviewers.
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