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This issue is affected by multiple factors, including sufficient coverage depths for genome assemblies, characteristics of genome assemblers (e.g., tolerance of variance in coverage depths), and characteristics of datasets and genomes (e.g., read biases and genomic structures that affect assemblies will make the subset selection harder).
Thus analysis on genomic structures that may affect gene expression regulation could shed light on the functions of genes.
In order to generate different genomic structures that may influence the success of imputation, four populations were simulated, which differed in the level of LD and the presence or absence of selection.
There appear to be a few genomic structures that are relevant to CMS, and finding these structures within rice cultivars and wild accessions provided us with the idea that genomic recombination events during rice breeding history diminished these unique genomic structures of CMS and, on the other hand, presumably gave rise to novel ORFs.
These studies have found that codon selection -- along with the number of tRNA and rRNA genes -- increases in bacteria with faster growth rates, suggesting that codon adaptation is one of several genomic structures that minimize generation time under optimal growth conditions [ 9, 24].
The final phase of microbial genome sequencing, particularly gap closing, is frequently the rate-limiting step either because of complex genomic structures that cause sequence bias even with high genomic coverage, or the presence of repeat sequences that may cause gaps in assembly.
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The class of single-gene HGLBs represents a genomic structure that allows for the potential identification of the target gene of one or a group of HCEs.
Because all eukaryotes likely share with budding yeast a genomic structure that features an abundance of short repetitive sequences, non-conservative recombination between unlinked repeats must be minimized in favor of conservative recombination so that genome stability can be maintained.
POU5F1 and POU2 share a five-exon genomic structure that is characteristic of the class V POU family.
A proposed mechanism includes differences in genomic structure that would make the 8q24 region more prone to subsequent somatic amplification [ 14].
For instance, the recently sequenced genome of the persistent (several millions of years) asexual metazoan bdelloid rotifer Adineta vaga revealed a genomic structure that is dominated by genomic rearrangements, mainly through mitotic recombination [ 15].
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