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Recent studies in human have found approximately 50% of genes have at least one alternative promoter and such genes tend to have significantly longer genomic structures including 5' and 3' UTRs, intron and exon lengths and numbers of exons compared to genes with single promoters ([27] and references therein).
However, the genomic structures, including intron-exon connections of the tunicate IRKs, showed considerable similarities to those of Caenorhabditis.
However, other genomic structures, including AT-rich palindromes and retroviruses, have also been reported to underlie recurrent structural rearrangements.
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Although genome size and overall genomic structure including gene number and gene order are well conserved, IR expansion/contraction is common in plant cp genomes.
Occasionally cells can emerge from senescence through immortalisation, where changes in genomic structure including telomere rescue occur [13].
Like many other malignancies, most breast cancers have significantly abnormal genomic structure, including aberrant numbers of chromosomes.
These elements have ubiquitous effects on underlying genomic structure, including alterations in the rates of recombination, production of genomic re-arrangements, and production of pseudogenization following insertion into gene coding sequences [ 30].
The HD-Zip I genes share intron and exon distribution (Ariel et al. 2007), and HvHox2 and its Poaceae orthologs have a similar genomic structure, including HD-Zip motif and peptide motifs (Fig. 2).
The genes in the sixth phylogenetic group, AtPDIL6-1, OsPDIL6-1 and TaPDIL6-1, presented a conserved genomic structure including four exons, whereas the moss P. patens PpPDIL6-1 exibited a single exon (Additional file 8).
Their genomic structure included the following exon numbers: 12 in TaPDIL2-1 and TaPDIL3-1; 11 in TaPDIL4-1; 9 in TaPDIL5-1; 4 in TaPDIL6-1; 5 in TaPDIL7-1 and TaPDIL7-2; 15 in TaPDIL8-1.
As shown in Table 1 and Figure S1, AP genes are significantly longer than SP genes in all aspects of the gene structure including genomic sequence, coding sequence (CDS), 5' untranslated regions (5' UTR), 3' UTR, total exon, and total intron.
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