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The recently released Brassica rapa draft genome provides an ideal opportunity to update our knowledge of the conserved genomic structures in Brassica, and to study evolutionary innovations of the mesohexaploid plant, B. rapa.
The presence of either natural or artificial amplicons has been exploited to obtain bacterial strains with alternative genomic structures, in some cases with improved desired characteristics.
The use of transposons and transposase is one promising method for transgenesis through stable transgene expression without tissue-specific repression, as well as efficient transgene insertion into genomic structures in species from insects to mammals.
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More than 20 other gene pairs in human genome were found to have the similar genomic structure in a genome-wide analysis, and it may represent a unique pattern of genomic arrangement that may affect expression regulation of the corresponding genes.
Seguin-Orlando, A. et al. Genomic structure in Europeans dating back at least 36,200 years.
The genomic structure in the dog is unique, with long haplotype blocks and extensive linkage disequilibrium.
Insertion of retroelements can disrupt genomic structure in several ways [4], [5], but can also disrupt gene regulation [6].
OXR1 has a complex genomic structure in the mosquito A. gambiae, and we confirm that multiple splice forms are expressed in adult females.
Conservation of this genomic structure in mammals indicates that a duplication event occurred prior to mammalian speciation in which the highly conserved sequences have been subsequently maintained in two homologous copies.
We defined a candidate cancer gene as recessive when affected by mutations potentially leading to loss of function; i.e. when it was frequently mutated in its coding region and frequently altered in its genomic structure, in particular deleted.
Our new data indicated that the SL-5S genomic structure [2] indeed occurred as a second genomic structure in almost all dinoflagellate species we examined; however, only the SL RNA structure (short, lacking Sm-binding site in the intron) we reported initially [1] can be detected either on Northern blot or through rapid amplification of cDNA 3' end of dinoflagellate SL RNA (Zhang et al. submitted).
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