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Beside the alteration of the order and orientation of genes through re-localization of pack-MULE elements, comparative analysis between the Nipponbare and CG14 S1 regions reveals changes of the genomic structure due to differential insertion or deletion of a multitude of transposable elements.
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The IFN cluster has very complicated genomic structures due to gene copy number variations and high similarity among these gene copies (fig. 7 G and H ).
Our results reveal a complex genomic architecture in the i(17q) breakpoint cluster region, characterized by large (∼38 49-kb ∼38 49-kbomic, low-copalindromic strongly suggesting that somatic rearrangements are not random events but rather reflect susceptibilities due to the genomic strepeats.
This observation was also echoed in an earlier report that proposed highly expressed genes could not be targeted by miRNA due to their shorter genomic structure [ 7].
Only 8 IgM ESTs (4 membrane and 4 secreted) were found to be expressed from zone 4 and, as expected due to its disorganized genomic structure, no EST from zone 3 was detected.
This is due in part to the genomic structure of the glycophorins' region, that encodes the GYPA, GYPB and GYPE highly homologous genes, and which might be affected by high rates of gene conversion among these loci.
In the duplicated (dp) mutant of I. nil, the mutation was due to the rearrangement of genomic structure by the Em/Spm transposable element [ 18].
Further analysis using different restriction enzymes and additional probes may help to delineate the genomic structure of the region but will still be challenging due to the presence of LCRs.
Within group A and B, elements have similar ends but differ drastically in structure due to insertions, deletions, and the incorporation of genomic DNA of other origin, often containing TE from other classes or superfamilies.
(C) Genomic structure of tyr.
Genomic structure is not equal across the species distribution.
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