Sentence examples for genomic structural changes from inspiring English sources

We aimed to elucidate the functional significance in evolutional changes in the genome structure, such as intron insertion and gene duplication, and the interactive relation between the expressed protein structure and the genomic structural changes.

It will be important to validate the relevance of those genomic rearrangements to cancer development since many of the genomic structural changes may be simply due to genome instability in cancer.

Once the genomic structural changes were defined in the rhesus macaque, together with the genome distribution of coding-genes across evolutionary regions, we further experimentally analyzed the meiotic recombination landscape as a way to explore the adaptive role of chromosomal changes.

Therefore, there is a need to develop a scalable approach for detecting such genomic structural changes in solid tumors where heterogeneous cell populations are present.

These genomic structural changes support the placement of Equisetales as sister to Ophioglossales + Psilotales and Marattiales as sister to Polypodiopsida.

The distribution of SD, CNV and UCE demonstrated that HKGs are also more conserved than TEGs with respect to genomic structural changes.

It can be expected that the rapid advancement of various ultra-high throughput technologies will likely make the sequencing-based approaches even more popular for a wide variety of studies including gene expression, transcription factor binding, genomic structural change, genome methylation and even de novo genome assemblies.

It has therefore been suggested that the vertebrate WGD events, occurring subsequent to amphioxus divergence, were symptoms of a pre-existing predisposition toward genomic structural change [78].

Interestingly, the presence of a genomic structural change, as well as gene dosage imbalance, contributes to the ultimate phenotype (Ricard et al, 2010).

To assess the broader genomic implications of structural changes at the HER2 locus, we investigated relationships between genomic instability and HER2 status in patients with invasive breast cancer.

We speculate that the genomic structural rearrangements induce changes in epigenetic marks and three-dimensional organisation of the region that are predictive of the observed expression changes.