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Clinically relevant imbalances were identified in 8 cases (14,8%) with genomic sizes ranging between 100 kb and 900 kb.
We calculated the resolution for single copy-number variations with genomic sizes ranging from 10 kb to 1 Mb, separately for gains and losses.
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The genome sizes ranged from 1.42 to 1.59 Mb with a genomic G + C content of 35 38% (supplementary table S3, Supplementary Material online).
Here we use a graduated series of Arabidopsis thaliana genomic deletion mutations (of sizes ranging from 4 bp to ~5 kb) to optimize CGH-based genomic deletion detection.
We extended this examination to the total number of 252 inversion loci identified between humans and chimpanzees and found that ∼30% of the inversion events (75/252) involved genomic deletions of variable sizes ranging from 94 bp to 11,012 bp.
The genome sequence of S. paratyphi C RKS4594 was determined by dye terminator chemistry on Megabace1000 and ABI3730 automated sequencers, with DNA clones from several pUC18 genomic shotgun libraries (insert sizes ranging from1.5 to 4.0 kb).
In order to estimate SNP false discovery rate (FDR), 30 large genomic regions of variable sizes (ranging from 2.7-10.5 Mb on variable positions at chromosomes 1, 3 and 10) were investigated where one individual from each of the 10 domesticated populations was clearly homozygous for a single haplotype.
Interestingly, when two haplotypes from two individuals were compared, three genomic copy number variants with sizes ranging from 1.6 to 17 kb were observed within the classical Class I gene region.
The final reconstructed genomic sequence of the ISA1307 strain is distributed over 154 scaffolds with sizes ranging from 2160 to 806 952 bp.
Following plant selection and genomic DNA extraction, five PE libraries of 300 bp and four MP libraries with insert sizes ranging from 1.5 to 10 kb were created.
In the 18.2 Mb sequence of chromosome 3B (Choulet et al. 2010), we identified 5455 in silico PstI-MseI fragments with sizes ranging from 30 to 1000 bp, which are similar to sizes observed in the genomic library profile.
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