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For nearly any q-value threshold at or below 0.358 (the highest reported by FIMO for the genomic set), more than double the number of occurrences of the motif sequence were found in the genome as a whole than in the coding sequences alone, implying a prevalence of statistically significant motif occurrences in non-coding regions (Fig. S1 and S2).
Individuals in the same species are assumed to share the same genomic set.
For the estimation of p-value in CpGhigh promoters and CpGlow promoters the sampling was done from the genomic set of CpGhigh promoters and the genomic set of CpGlow promoters, respectively.
A second feature from our genomic set which was predictive of essentiality was the total upstream size of a gene.
A histogram of FR values in the genomic set of mouse promoters is shown in Fig. 1A.
Fig. 1B shows a plot of the difference in GC content between pairs of motifs versus FR for the genomic set of mouse promoter sequences.
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The frequency with which each model was found to be the best-fit model across the genome varied considerably among the different genomic sets (table 2).
Allopolyploids are usually formed by interspecific hybridization concurrent to genome duplication, but could also result from diploidization and divergence of genomic sets in an autopolyploid [ 30].
Although an exhaustive search would be ideal, it is not generally practical in the genomic setting.
The genomic set-up of GBMs is increasingly well characterized [ 11, 13, 14], allowing the identification of certain signature alterations.
This can be employed in post-genomic functional genomic set-ups, where underlying metabolic network should provide a scaffold for annotation, e.g. one can assume that all enzymes in an essential pathway should be present in the genome, and use that knowledge to find best gene candidates for all steps in the pathway [ 30].
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