Computational translation of genomic responses from experimental model systems to humans.
Dhahbi, J. M., Kim, H. J., Mote, P. L., Beaver, R. J. & Spindler, S. R. Temporal linkage between the phenotypic and genomic responses to caloric restriction.
Shay T, Lederer JA, Benoist C. Genomic responses to inflammation in mouse models mimic humans: we concur, apples to oranges comparisons won't do.
This study is an informative overview of the genomic responses after burn injuries.
Thus, this technology can be used to agnostically quantify genomic responses for which the underlying mechanism remains unknown.
Also, similar leukocyte genomic responses to inflammation may be involved in both trauma and sepsis patients [30].
Our genomic responses turned out to be very similar to that of yeast.
Liver genomic responses to ciguatoxin: evidence for activation of phase I and phase II detoxification pathways following an acute hypothermic response in mice.
Changes in the gene expression profile, assessed at different time points after endotoxemia, displayed a very low correlation between human and mouse genomic responses thereby raising an important concern about the usefulness of mouse models in sepsis research.
This may be explained by the finding that the genomic responses to different acute inflammatory stresses, including trauma, burns, and endotoxemia/sepsis are highly similar in humans; however, these responses are not reproduced in mouse models [32].
Interestingly, when comparing genomic responses of the two severity groups, we observed that the overall changes (direction of the responses) in gene expression at H0 between these groups were very similar.
