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Although the two severity groups seemed to have the same genomic response at H0, the number of altered genes in SAPSII-low patients decreased over the 48 h study period, returning to control values, whereas it remained stable in the SAPSII-high group even with a trend toward increase (Figure 4C).
We investigated the genomic response at the level of mRNA expression to the deletion of SSA1/2 in comparison with the mild heat-shocked wild-type using cDNA microarray.
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Lastly, ICE-FIRST gave us our first glimpse at the genomic response to spaceflight, suggesting that altered Insulin and/or TGF-beta signaling in flight may underlie many of the biological changes seen in response to spaceflight.
Microarray expression data was obtained from a global gene expression study aimed at assessing the genomic response to radiation conducted by Yunis et al. [ 15].
Overall, the genomic response induced by 520 mg/l SDD at day 8 was more similar to that induced by nonmutagenic than by mutagenic carcinogens.
Rather than targeting a single gene or signaling pathway, we chose a systematic approach aimed at targeting the overall genomic response to chronic cytokine stimulation.
Genomic response to nanoparticles is used to assess toxicological impact at genetic levels using S. cerevisiae as a model eukaryote [7, 8, 9, 10].
This data supports the concept that the large differences seen in the genomic response to injury in skin and mucosa are derived of at least in part from intrinsic differences in the genetic regulation of cells at each site.
The trend of the response was similar in both groups, and differences were observed only at the level and the duration of the genomic response between the two severity groups.
He had worked with all kinds of researchers, trying to find a genomic response to everything from yoga to meditation to tai chi.
Pan-genomic analyses offer an interesting opportunity to study global genomic response within the very first hours after sepsis.
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