Sentence examples for genomic profiling technologies from inspiring English sources

This study aims to document longitudinal changes in the uptake of genomic profiling technologies and systemic chemotherapy, and to assess the impact of new evidence on local protocol.

Hypermethylation of CGI promoters was classically believed to directly drive carcinogenesis by silencing tumor suppressor genes 8. Studies using genomic profiling technologies have conclusively demonstrated that this is not the case for the vast majority of aberrantly hypermethylated genes, as they are already silenced in the corresponding normal cells that give rise to cancer 11– 11.

The advent of genomic profiling technology has brought about revolutionary changes in our understanding of breast cancer metastasis.

Typically, genomic variables are tested for the associations with external variables, which are measured independently of genomic profiling technology, such as disease status, treatment labels, or time points.

The advent of genomic profiling technology has led to paradigm-shifting advances in the conceptual and mechanistic understanding of the metastatic process over the past decade.

Oncologists have voiced similar concerns with other tests that use genomic tumor profiling technologies such as those currently used for early-stage breast cancer [ 26, 27].

Nonetheless, the decrease in costs for genomic and epigenetic profiling technologies should allow the field to cope with these sources of variability when setting up batteries of iPSC lines that may complement clinical studies.

Secondly, global high-resolution genomic profiling using current technologies requires high-quality genomic material such as that derived from fresh tissue.

Nevertheless, rapid translation of these findings to a clinical setting has been limited because of the need to use genomic and transcriptomic profiling, technologies that are not routinely available in most pathology laboratories.

Open-architecture, whole-genome transcription profiling technologies such as SuperSAGE [ 6], however, provide a solution to the problem of lacking EST and genomic data.

The introduction of array-based platforms has therefore greatly improved genomic profiling and currently, two technologies are mainly used for screening of DNA copy number; the BAC (Bacterial Artificial Chromosome) and the oligonucleotide-based CGH arrays.