Modern molecular and genomic profiling of cancer allows for a far more accurate prediction of survival.
However, genomic profiling of papillary thyroid cancer (PTC) cases from Taiwan has not been attempted previously.
The last decade has witnessed a transformation in our understanding of the genetic basis of ALL due to detailed integrative genomic profiling of large cohorts of childhood ALL.
Genomic profiling of human cancers provides us with unprecedented insight into the mutational landscape of genes directly or indirectly involved in the response to radiation-induced DNA damage.
Genomic profiling of pancreatic islets in non-diabetic and diabetic states is needed in order to dissect the contribution of epigenetic mechanisms to the declining proliferation potential of β cells that we see with aging or the β-cell failure observed in diabetes.
A pilot study involving genomic profiling of six Falun Dafa practitioners indicated that, "changes in gene expression of [Falun Gong] practitioners in contrast to normal healthy controls were characterized by enhanced immunity, downregulation of cellular metabolism, and alteration of apoptotic genes in favor of a rapid resolution of inflammation".
These findings were concordant with genomic profiling of tumors the EGFR signaling class.
Wide dynamic range and high signal to noise ratio facilitates sequence-based genomic profiling of low abundance transcripts, which cannot be reliably detected using microarrays.
However, incorporation of such information into clinical decision-making requires reliable genomic profiling of frozen, paraffin-derived, and archival tumor DNA.
Metabonomic and genomic profiling of patients' responses to drug interventions can provide novel information about the in vivo metabolism of low-molecular-weight compounds and extend our insight into the mechanism of drug resistance.
In summary, transcriptional and genomic profiling of 52 commonly used breast cancer cell lines identifies cell line subtypes, and defines the cell line subtypes that most faithfully capture the known heterogeneity of breast tumors.
