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For example, Ju et al. [ 37] and Haffner et al. [ 38] report that strand breaks may be a part of other genomic processes, including transcription.
Via controlling access to the DNA, chromatin enables the accurate regulation of all genomic processes including DNA repair, DNA replication, and transcription.
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The extraordinary diversity of secondary metabolite gene clusters found in these microbes is likely the result of their existence in hostile ecological niches and consequent genomic evolutionary processes including large scale rearrangements, insertions and deletions to cope with these exigencies.
These epigenetic mechanisms establish and maintain core biological processes, including genomic imprinting and entrainment of circadian rhythms.
Elucidating how DNA methylation marks are established in the germline has been a challenge for nearly 20 years, but represents a key step towards a full understanding of several biological processes including genomic imprinting, epigenetic reprogramming and the establishment of the pluripotent state in early embryos.
These mechanisms are essential for regular growth and related to a number of key processes including: genomic imprinting, X-chromosome inactivation, suppression of identical elements, the aging process, and carcinogenesis (Lister et al. 2009; Rana and Ankri 2016).
BRCA1 is a multifunctional protein that has been implicated in many cellular processes, including genomic stability, the cell-cycle checkpoint, DNA-damage repair, apoptosis, and gene transcription [1].
FUS is a multifunctional protein essential for a diverse host of cellular processes, including genomic stability, RNA metabolism, and stress response.
DNA methylation plays an important role in numerous processes, including genomic imprinting, cellular differentiation, embryonic development, X-chromosome inactivation and chromosome stability.
DOI: http://dx.doi.org/10.7554/eLife.00726.002 DNA methylation is an ancient and major epigenetic modification that plays an important role in key biological processes, including genomic imprinting, X-chromosome inactivation, suppression of transposable elements, and carcinogenesis (Jaenisch and Bird, 2003; Egger et al., 2004; Robertson, 2005; Feinberg, 2007; Reik, 2007).
As a result, DNA methylation is involved in a diverse range of processes including embryogenesis, genomic imprinting, cellular differentiation, DNA-protein interactions, and gene regulation [ 1].
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