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Our preliminary estimate of the hazard ratio (HR) associated with Active (compared to Inactive) microenvironment was approximately 2.5, which is substantial considering that established genomic phenotypes such as p53 mutation status [ 34] and Cyclin E overexpression [ 35] have HRs near two.
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We suggest that by treating the whole genome as a quantitative variable and deriving a genomic phenotype (phenome), we are able to observe epistatic effects among genes that lead to linkage disequilibrium among members of the genomic core.
Paternal age has previously been associated with another genomic phenotype, increased telomere length, indicating that, in principal, global genomic properties can be sensitive to paternal age[42], [43].
Genomic phenotyping was performed to detect CG-1521-sensitive CG-1521-sensitive CG-1521-sensitive
PharmGKB contains genomic, phenotype and clinical information collected from PGx studies.
Previous genomic phenotyping on solid agar did not find 'telomere maintenance' enriched among MMS sensitive strains [ 2].
Our results identify mutation load as a quantitative genomic phenotype, rather than a genotype, associated with clinical outcome.
Findings from this study outline a relationship between functional changes and the underlying genomic phenotype to improve understanding of differential effects of hyperglycemia on endothelial cells.
Identifying genomic phenotype and corresponding functional changes in hyperglycemic endothelial dysfunction will provide a suitable systems biology approach for understanding underlying mechanisms and possible effective therapeutic intervention.
Genomic phenotyping with the S. cerevisiae strain BY4741 and single-gene deletion mutant derivatives corresponding to the nonessential yeast genes was performed as previously described [ 1, 5].
Additionally, we have worked to better caveat the work throughout to reflect the link to quantitative analysis of organelles in a genomic phenotype.
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