Sentence examples for genomic pathway from inspiring English sources
Ligand-activated ERs drive gene cascades comprising primary genes, whose transcription is directly controlled by the hormone through physical interaction of ERs with regulatory sites in the genome (genomic pathway) and/or with signal transduction effectors (non genomic pathway), as well as downstream genes whose activity depends upon the functions encoded by the primary responders [ 1, 4].
In hormone-dependent breast cancer, estrogen receptors are the principal signaling molecules that regulate several cell functions either by the genomic pathway acting directly as transcription factors in the nucleus or by the non-genomic pathway interacting with other receptors and their adjacent pathways like EGFR/IGFR.
We recently described a genomic pathway approach to study complex diseases.
We also thank our collaborator John Ioannidis for useful discussion and advice regarding our genomic pathway approach.
Importantly, genomic pathway cluster designation remained within the model as an important predictor of clinical outcome (cluster 1 vs. cluster 4; HR 4.31, p = 0.18) (Table 1).
By contrast, our genomic pathway approach suggests that even for disorders that appear sporadic, genetic factors may still play a major role.
Transient and continuous administrations equally increased eNOS expression, implying that a short contact between hormone and cells is sufficient to trigger genomic pathways.
Conclusions: Our data suggest that the kinetics of contact of estrogen with the cells could represent a sensor for estrogen receptor (ER) signaling towards non-genomic or genomic pathways.
Our findings for axon guidance and ALS or PD do not preclude the role of other genomic pathways in the etiology of these disorders.
Further studies based on transcriptomic and proteomic approaches are now necessary to precise the functional consequences of the genomic pathways we have characterized here, taking into account the other molecular characteristics of CRCs.
Thus, imaging-genomic analyses may prove invaluable in detecting novel targetable genomic pathways.
