Exact(18)
In this study, using whole-genome gene expression microarrays we identified main drug-responsive genomic networks that are regulated by 18 individual psychoactive drugs known to impact on one or more pharmacological targets within the striatum.
This is just what evolution needs to rewire genomic networks at times of evolutionary challenge, especially when similar changes have to occur at more than one locus (McClintock 1956).
Global organization of genes into pathways and their interactions can be identified through construction of genomic networks.
The latter observation relates the SS to a recently observed class of molecular biology phenomena, such as protein networks and more in general of genomic interaction networks [26], [28] and draws a bridge between phenomena whose underlying mechanism is a language, words for the SS and the DNA alphabet for the genomic networks.
Conceivably, similar mechanisms might underlie aging-related alterations in GC signaling in selective hippocampal genomic networks.
Cancer is a genetic disease a result of dysregulation of genomic networks [ 18].
Similar(42)
QPCR primers for candidate genes were designed with the software CloneManager (Sci-Ed Software, [ 58]) using the corresponding sequences of the tomato genome (sol genomic network, [ 59]) (for primer sequences see Additional file 2: Table S3).
Seven other COSII markers were identified comparing the sequences of SSRs mapped with the tomato genome database (Sol Genomic Network).
In June, he published a pet project, the DNA sequence of the currant tomato — the wild ancestor of them all — online at the Sol Genomic Network, a database containing research on the nightshade family, of which tomatoes are a member.
The identified genes were overlaid on the genomic network from the Ingenuity database and labeled as Focus genes.
The existence of attractor selection in genome-encoded networks should be investigated in future studies, although the response of the whole genomic network in terms of attractor selection will be not as simple as that described here as it will involve combinations of many molecular mechanisms, including canonical signal transduction pathways.
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