The phrase "genomic mutation" is correct and commonly used in written English.
It refers to a change or alteration in the genetic material (genome) of an organism. Example: "The scientists discovered a rare genomic mutation in the patient's DNA, which explained her increased risk for developing a certain type of cancer."
In this comparison, both model populations had the same genome size and genomic mutation rate.
Author response: We agree that for RNA-based viral genomes, which often have genomic mutation rates 1000 times greater than DNA-based organisms, double mutations occur frequently.
In this case we used the "COPY_MUT_PROB" in the "GENESIS" file, which is the mutation rate that results from dividing the genomic mutation rate by the genome size.
No homologs of the conserved mismatch repair genes, mutS and mutL, have been found in the genome of S. acidocaldarius despite its low genomic mutation rate, leading to the puzzling question of what is responsible for the maintenance of the low genomic mutation rate observed in this organism and in the Archaea as a whole [4], [5], [46].
Escherichia and Salmonella have genomic mutation rates of ∼10−3/generation, ∼5 Mb genomes, estimated average doubling times of 40 h in nature [33], and an input of polymorphisms by recombination 2.5 times higher than that of mutation [26].
In this study, we examined the cancer genomes of HPR NSCLCs to identify the genomic mutation profile associated with prolonged exposure to smoky coal pollutants.
Deng and Lynch's (2) procedures were employed to estimate the genomic mutation rate (U), mean dominance coefficient, mean selection coefficient, and scaled genomic mutational variance.
The different level of genomic diversity measured in nuclear and chloroplast genomes can be attributed to their disparate method of inheritance and the genomic mutation rate.
A main genomic mutation parameter is estimated that describes the average number of synonymous changes genome wide, and then departures from this main effect at the gene level are explored in the framework of a log linear model.
In addition to large chromosomal alterations, genomic mutation is another important genetic alteration which contributes to tumor initiation and progression.
This is especially useful when handling the large fragments for recombination analyses, genomic mutation, or inserting a foreign open-reading frame into the infectious clone.
