Sentence examples for genomic modification of from inspiring English sources
The genomic modification of endogenous genes encoding TrpEP290S, AroF-1P148L, and PheAT310I, and the deletion of pykA improved phenol production 17-fold, while also minimizing the burden caused by plasmids and auxotrophies.
Nuclease-mediated genomic modification of somatic cells coupled with somatic cell nuclear transfer (SCNT) provide a new approach for creating genetically modified animal models and allow for the direct comparison of mutations in an otherwise isogenic setting.
AR reactivation can occur directly through genomic modification of the AR gene, or indirectly via co-factor and co-chaperone deregulation.
33 We also established a transgenic production protocol based on a nonviral system for the genomic modification of chicken PGCs and the creation of transgenic birds using the piggyBac transposon and germline-competent chicken PGCs.
Because this genomic diversity is unusual among vertebrates, salamanders provide a rare opportunity to test the effects of genomic modification on vertebrate mitochondrial gene sequence evolution.
In recent studies, zinc finger nuclease (ZFN -mediated genomic modification rates of 3% - 100% for specific genes have been reported in ZFN -mediatedabidopsis, and rat [ 4- 16].
Engineered homing endonucleases proteins are now being used to generate targeted genomic modifications for a variety of biotech and medical applications.
To better understand the patterns of genomic modification imposed by selection, profiles of 52,041 SNPs were characterized in 342 soybean landraces and 1062 improved lines.
This has enabled successfully large quantities of genomic modification via electroporation, microinjections or lipid-mediated transfection.
Selected ZFN pairs were tested for the ability to induce sequence changes in a Cel1 assay and we observed frequencies of genomic modification up to 18.7% at the endogenous hTERT locus.
In ZFNGenome, the incorporation of "uniqueness" and ZiFOpT "confidence" scores (42) should help improve the time and cost-effectiveness of genomic modification experiments utilizing ZFNs.
