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Having selected a genomic model and a collection of genome operations to consider, the standard algorithmic problem is the computation of the distance between two genomes π and Γ, or the minimum number of allowable operations required to transform π into Γ; the more difficult problem of sorting demands the operations themselves.
A set of 118 IPF prognostic predictor genes was used to derive the functional genomic model and PI.
In all cases the 86% of genotypes were used to train the genomic model and the predictions were assessed in the other 14%.
Briefly, 10%% of patients were randomly omitted leaving the remaining 90%% of patients to construct the genomic model and derive a PI for each of the omitted samples.
Subsequently, the combined GEBV of the validation bulls were compared with their actual deregressed EBV to validate the genomic model and to check the consistency of the genetic trend and variance based on GEBV versus EBV according to the Interbull genomic validation test procedure [ 24].
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The significance of the dominance variance was tested by comparing twice the difference in log-likelihood between additive genomic model (AM) and additive and dominance genomic model (ADM) to a chi-squared distribution with degrees of freedom of 1.
Estimates of genetic variance using the additive genomic model (AM) and the model fitting both additive and dominance genetic effects (additive-dominance genomic model, ADM) are in Table 3 for each trait.
(XLSX 9 kb) Additional file 6: Kaplan Meier curves for the validation set of ADC and SCC using the genomic model (A) and the clinical-genomic model (B) highlighted in red.
The study demonstrated how integrating GWAS data into functional genomic, model organism and clinical information can uncover basic biological pathways that are associated with disease outcome.
In the random selection scenario, the base PEV reliabilities and reliabilities of selection were equal, within the bounds of sampling, for both the pedigree model and the genomic model (Table 2) and, therefore, only base PEV reliabilities will be described.
Pedigree and genomic evaluations differed in the specification of the covariance structure for a; Va = A σ A,02 for the pedigree model and Va = G σ A,02 for the genomic model, where A and G are the respective relationship matrices based on pedigree [ 2] and genome-wide marker genotypes [ 27].
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