As genome sequences become available for more species, this "genomic" method of phylogenetic analysis should enable robust estimation of orthology and paralogy among related genes.
These results not only agree with the current hypotheses regarding the mechanism of GBS/MFS but also concur with a recent study in which GBS/MFS strains and enteritis-control strains were screened for potential neuropathogenic markers using the high resolution comparative genomic method of high-throughput Amplified Fragment Length Polymorphism (htAFLP) [ 44].
The genotypic diversity evidenced by sub-genomic methods of analysis suggests that whole genome analyses of T. cruzi strain diversity would be fruitful, especially for elucidating the underpinnings of strain diversity in biological characteristics, such as variability in complements of large gene family members.
Ultimately, an exhaustive gene network can be constructed, if all synthetic lethal phenotypes are analyzed [ 3], aiding in post-genomic methods of drug discovery [ 4].
) Introduction to basic computational and genomic methods for analysis of biological systems.
Efficient methods have been developed for the genetic manipulation and the heterologous expression of the clusters, and more than 100 new derivatives of these antibiotics have been generated by metabolic engineering, mutasynthesis and chemoenzymatic synthesis, providing a model for the power of genetic and genomic methods for the generation of new bioactive compounds.
In the present work however, we perform whole genome comparisons of 32 Brucella genomes (Table 1) using a variety of different genomic methods to obtain deeper insight into the obscure evolution of genus Brucella.
The application of genomic methods to reveal both DNA sequence and to calculate quantitative digital values for gene expression has the potential to improve our understanding of patient subpopulations with the most common and complex forms of these diseases.
The group simulated blooms in phytoplankton communities in the North Pacific by mixing nutrient-rich deeper water with shallow-water communities and using genomic methods to track the responses of individual species.
This notion has been reinforced by the surprising ineffectiveness of comparative genomic methods for identifying regulatory sequences in the invertebrate taxa where they have been applied.
