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Recent studies including several genomic methods like DNA microarrays, optical mapping, and whole genome sequencing have shed new light on the level of diversity within bacterial populations, making it clear that the level of genomic diversity had been grossly underestimated previously [ 7- 9].
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In the near future, new genomic methods will allow the detection of a new pathogenic Borrelia species (like Borrelia Miyamotoi) and allow a better identification of various microbial agents responsible for co-infections".
) Introduction to basic computational and genomic methods for analysis of biological systems.
Genomic methods described include protocols for transcriptomics, shotgun proteomics, interactomics, metabolic profiling, and lipidomics.
Genomic methods represent all genes equally.
Genomic method is more sensitive than other techniques looking for lingering cells post-chemotherapy.
For methods like MultiZ, improperly assembled genomic segments may provide misleading information about orthologous relationships.
The global content of 5-methyl cytosine could be more accurately measured by methods like total digestion of genomic DNA to nucleotide or nucleoside levels and further separation by HPLC or by capillary electrophoresis.
New cytogenetic methods like FISH, array-CGH (comparative genomic hybridization), SKY (spectral karyotype), and MCB (multicolor banding) are considered complementary analyses for conventional cytogenetic.
When roughly analyzing large genomic regions or large numbers of regulatory modules, traditional methods like phastCons may correctly predict the majority of binding sites.
Our estimates of genomic islands in PCC 7942 are larger than those predicted by other published methods like SIGI-HMM.
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