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Although functional genomic methods have provided considerable advances to our understanding of gene regulation, these assays, which are usually performed on a genome-wide scale, typically provide correlative observations that lack functional interpretation.
Recent studies utilizing microbial genomic methods have demonstrated that chronic wounds are host to a wide range of microorganisms.
Comparative genomic methods have been successfully used to address the first challenge many times, but there are not yet effective methods to address the second challenge.
While there have been some successes in these organisms (e.g. [16]), comparative genomic methods have not yielded the expected bounty of regulatory sequences.
The results of profiling miRNA using genomic methods have proven to be very platform dependent.
In the meantime, genomic methods have generated incremental advances in our understanding of inflammation.
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The sequencing of the human genome and the development of new genomic methods has resulted in an explosion in our understanding of the molecular basis of disease, and a consequent explosion in the complexity of molecular diagnostic tests.
The rapid development of genomic methods has posed an important question, namely where do genetics and genomics sit in relation to their application in the conservation of species?
Meta-genomic methods have demonstrated the presence of Archaea in some diseased tissues 10– 15, but archaeal pathogens have not been found.
The development of post-genomic methods has dramatically increased the amount of qualitative and quantitative data available to understand how ecological complexity is shaped.
In dairy cattle routine genomic evaluations, different genomic prediction methods have been implemented by different countries and organisations [ 23].
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