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The sequencing of the human genome and the development of new genomic methods has resulted in an explosion in our understanding of the molecular basis of disease, and a consequent explosion in the complexity of molecular diagnostic tests.
The rapid development of genomic methods has posed an important question, namely where do genetics and genomics sit in relation to their application in the conservation of species?
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Although functional genomic methods have provided considerable advances to our understanding of gene regulation, these assays, which are usually performed on a genome-wide scale, typically provide correlative observations that lack functional interpretation.
Comparative genomic methods have been successfully used to address the first challenge many times, but there are not yet effective methods to address the second challenge.
While there have been some successes in these organisms (e.g. [16]), comparative genomic methods have not yielded the expected bounty of regulatory sequences.
The results of profiling miRNA using genomic methods have proven to be very platform dependent.
In the meantime, genomic methods have generated incremental advances in our understanding of inflammation.
Single-cell genomic methods have the capacity to resolve complex mixtures of cells in tumors.
Genomic methods have only recently become feasible for non-model organisms, such as spiders, with the advent of next generation sequencing technologies [ 39- 41].
Several comparative genomic methods have been applied to CRM and motif prediction (Ray et al., 2008; Siddharthan et al., 2004; Sinha and He, 2007; Sinha et al., 2004).
The development of post-genomic methods has dramatically increased the amount of qualitative and quantitative data available to understand how ecological complexity is shaped.
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