Our findings suggest that while specialised training of experienced research staff could improve communication about the genomic methods of the research during the consent process, this will not necessarily be a topic of particular interest to individual participants.
Porcu et al. utilized a genomic method to globally analyze effects of FTIs on cellular activity.
In the absence of a genomic method for estimating percent normal, we used pathologist assessment where available, or selected a uniform value of a across each dataset/population.
Efficient methods have been developed for the genetic manipulation and the heterologous expression of the clusters, and more than 100 new derivatives of these antibiotics have been generated by metabolic engineering, mutasynthesis and chemoenzymatic synthesis, providing a model for the power of genetic and genomic methods for the generation of new bioactive compounds.
The genotypic diversity evidenced by sub-genomic methods of analysis suggests that whole genome analyses of T. cruzi strain diversity would be fruitful, especially for elucidating the underpinnings of strain diversity in biological characteristics, such as variability in complements of large gene family members.
In the present work however, we perform whole genome comparisons of 32 Brucella genomes (Table 1) using a variety of different genomic methods to obtain deeper insight into the obscure evolution of genus Brucella.
While the use of "genomic" methods to facilitate property prediction, virtual design, and discovery of materials is relatively new, the concepts driving the development of materials informatics are based, solidly, on the lessons learned during the development history of cheminformatics and bioinformatics.
Ultimately, an exhaustive gene network can be constructed, if all synthetic lethal phenotypes are analyzed [ 3], aiding in post-genomic methods of drug discovery [ 4].
The application of genomic methods to reveal both DNA sequence and to calculate quantitative digital values for gene expression has the potential to improve our understanding of patient subpopulations with the most common and complex forms of these diseases.
