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This genomic signature pattern was already observed in several vertebrate viruses with small genomes, regardless of their genomic material [43], [55].
We have additional genomic material such as the mitochondrial genome, with little understanding of how these interact with genetic elements in the nucleus.
However, approaches for genome closure such as primer walking could be attempted on the amplified viral genomic material if complete coverage is critical.
Parasites are living organisms that feed off of other organisms; viruses are unique sequences of genomic material which can cause a disruption or aberration of normal biological function.
Deep-freezing lets us preserve genomic material, like ribonucleic acid, that is easily degraded.
Recent data also implicate rare insertions and deletions of genomic material that may have pleiotropic effects on multiple conditions.
DNA removal in RNA samples is essential to prevent the incorporation of any genomic material in the RNA-Seq library and consequently the misinterpretation of RNA-Seq data analyses.
Thus, other forms of variation are likely involved, such as epigenetic factors, that may be able to confer changes to the genomic material to be inherited without altering the genetic code.
While much is known about DNA structure on the basepair level, this scale represents only a fraction of the structural levels involved in folding the genomic material.
We constructed a normalized polyphenic expressed sequence tag (EST) library that represents genomic material from most of the castes and life stages of the Formosan subterranean termite.
A key factor regarding VLP safety is the lack of viral genomic material, which enhances safety during both manufacture and administration.
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